Bioinformatics Question bank

                                   

ZOUT 121: MolecularBiology and Bioinformatics.

1. Bioinformaticsa)     What is Bioinformatics
b)     Bioinformatics web resource?
c)      NCBI
d)     EBI
e)     Expasy
f)       Pubmed
g)     OMIA
h)     Applications of Bioinformatics
2. Databases – Tools and their usesa)     What is a biological database?
b)     What are primary databases?
c)      What Nucleic acid databases
d)     What is genbank- EMBL-EBI- DDBJ
e)     What Protein sequence data bases
f)       What Secondary sequence databases,
g)     PROSITE, BLOCKS, Pfam/ Prodom,
h)     Bibliographic
 3. Sequence alignment methodsa)     Blast, Fasta and its Significance of sequence alignment
b)     What is Pairwise sequence alignment?
c)      What is multiple sequence alignment (PRAS, CLUSTALW)
d)     State the difference between global & local alignment
 4. Predictive applications using DNA and protein sequencesa)     What is Evolution,
b)      Type of Evolution,
c)      Application of phylogenetic trees.
d)     What is Pharmacogenomics
e)     Pharmacogenomics application.
f)       Parsimony and Bayesian approaches.
g)     Different types of protein chip.
h)     What is Proteomics
i)       Applications of Proteomics.
j)       What is metabolomics and applications.  
k)     Synonymous and non-synonymos substitutions.